期刊
PNAS NEXUS
卷 1, 期 4, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/pnasnexus/pgac140
关键词
nanomatryoshka; MRI contrast agents; gadolinium; gadolinium oxide; photothermal cancer therapy
资金
- Carl and Lillian Illig Fellowship
- Welch Foundation [C-1220, C-1222]
This study reports a novel nanoparticle Gd2O3-NM, which is a multilayered nanoparticle structure capable of both magnetic resonance imaging (MRI) and photothermal therapy (PTT). Gd2O3-NM exhibits excellent stability and imaging performance, providing a new option for tumor treatment and diagnosis.
Nanoparticle-assisted laser-induced photothermal therapy (PTT) is a promising method for cancer treatment; yet, visualization of nanoparticle uptake and photothermal response remain a critical challenge. Here, we report a magnetic resonance imaging-active nanomatryoshka (Gd2O3-NM), a multilayered (Au core/Gd2O3 shell/Au shell) sub-100 nm nanoparticle capable of combining T-1 MRI contrast with PTT. This bifunctional nanoparticle demonstrates an r(1) of 1.28 x 10(8) mM(-1) s(-1), an MRI contrast enhancement per nanoparticle sufficient for T-1 imaging in addition to tumor ablation. Gd2O3-NM also shows excellent stability in an acidic environment, retaining 99% of the internal Gd(3). This report details the synthesis and characterization of a promising system for combined theranostic nanoparticle tracking and PTT.
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