3.8 Review

The role of roof plate-specific spondins in liver homeostasis and disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Gastroenterology & Hepatology

Liver zonation, revisited

Jasmin Paris et al.

Summary: The concept of hepatocyte functional zonation has been greatly advanced by recent advances in single-cell genomics technologies, allowing for the emergence of novel precision medicine-based therapies for liver disease.

HEPATOLOGY (2022)

Review Gastroenterology & Hepatology

The RSPO-LGR4/5-ZNRF3/RNF43 module in liver homeostasis, regeneration, and disease

Stefano Annunziato et al.

Summary: WNT/β-catenin signaling is key in liver development, homeostasis, and regeneration, but its dysregulation can lead to hepatic tumors. The RSPO-LGR4/5-ZNRF3/RNF43 module fine-tunes WNT/β-catenin signaling and may offer targets for novel therapies. Controversy surrounds LGR5 as a marker for liver stem cells.

HEPATOLOGY (2022)

Article Cell & Tissue Engineering

RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis

Chanyi Lu et al.

Summary: The study reveals the important roles of RNF43/ZNRF3 in regulating taste and lingual epithelial tissue homeostasis. R-spondin interacts with RNF43/ZNRF3 to enhance WNT signaling, thereby controlling taste cell regeneration and lingual epithelial tissue homeostasis.

STEM CELL REPORTS (2022)

Review Pharmacology & Pharmacy

Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma

Danyu Du et al.

Summary: Hepatocellular carcinoma is an aggressive cancer with increasing incidence worldwide. Targeting abnormal metabolism has emerged as a new strategy for HCC treatment. This review highlights metabolic targets and discusses current pharmaceutical agents and studies in this field.

ACTA PHARMACEUTICA SINICA B (2022)

Review Biochemistry & Molecular Biology

Exploring the Wnt Pathway as a Therapeutic Target for Prostate Cancer

Sarah Koushyar et al.

Summary: Aberrant activation of the Wnt pathway is closely related to tumor formation, progression, and therapeutic resistance in prostate cancer. Targeting the Wnt pathway for prostate cancer treatment has shown potential efficacy. However, the functional consequences of activating the Wnt pathway during different stages of prostate cancer progression are still unclear. Preclinical research on targeting Wnt signaling in the treatment of prostate cancer is crucial for identifying effective treatment strategies and improving patient care.

BIOMOLECULES (2022)

Review Gastroenterology & Hepatology

Intercellular crosstalk of liver sinusoidal endothelial cells in liver fibrosis, cirrhosis and hepatocellular carcinoma

Hui Li

Summary: Intercellular crosstalk among various liver cells is crucial in liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The interaction between liver sinusoidal endothelial cells (LSECs) and other liver cells plays a vital role in the development and progression of liver fibrosis, and is closely related to the immunosuppressive tumor microenvironment (TME).

DIGESTIVE AND LIVER DISEASE (2022)

Article Medicine, Research & Experimental

RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis

Zhiying Yue et al.

Summary: The study shows that osteoclast precursors can act as a component of the premetastatic niche for breast cancer bone metastasis by regulating the expression of DKK1 through the RSPO2/RANKL-LGR4 signaling pathway, leading to enhanced metastasis formation.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Article Endocrinology & Metabolism

Identification of a regulatory pathway inhibiting adipogenesis via RSPO2

Hua Dong et al.

Summary: Dong and Sun et al. demonstrate the inhibitory role of adipogenesis regulatory cells in murine white adipose tissue through RSPO2. They show that RSPO2 regulates the maturation of early progenitor cells via Lgr4. This study highlights the importance of cellular crosstalk in adipogenesis and its impact on adipose tissue homeostasis.

NATURE METABOLISM (2022)

Review Biochemistry & Molecular Biology

The role of R-spondin proteins in cancer biology

Eline J. ter Steege et al.

Summary: RSPO proteins play a crucial role in activating the Wnt/beta-catenin signaling pathway in stem cells and progenitor cells. Deregulation of RSPOs has been implicated in various cancer types, with potential for therapeutic targeting in cancer cases with RSPO overrepresentation.

ONCOGENE (2021)

Review Neurosciences

SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity

Vania Sepulveda et al.

Summary: Cerebrospinal fluid is a vital clear fluid for the central nervous system, while SCO-spondin, a large glycoprotein, with matricellular protein and ligand-binding properties, may play a crucial role in regulating cerebrospinal fluid activity.

FLUIDS AND BARRIERS OF THE CNS (2021)

Review Oncology

WNT as a Driver and Dependency in Cancer

Marie J. Parsons et al.

Summary: The WNT signaling pathway plays a critical role in various cancer types, with distinct patterns of dysregulation and immune evasion mechanisms. Targeting the oncogenic effects of WNT signaling is a current focus of research in developing therapeutic strategies for cancer treatment.

CANCER DISCOVERY (2021)

Article Oncology

Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids

Md Soriful Islam et al.

Summary: Injections of collagenase into uterine fibroids led to a reduction in stiffness, inhibited cell growth, and decreased key factors promoting fibroid growth. Inhibition of YAP signaling pathway showed promising effects in suppressing cell proliferation and fibrosis-related pathways in fibroid cells, suggesting a potential therapeutic strategy for uterine fibroids.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Review Anatomy & Morphology

The Hepatic Central Vein: Structure, Fibrosis, and Role in Liver Biology

Ki M. Mak et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Challenges in liver cancer and possible treatment approaches

David Anwanwan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Article Biochemistry & Molecular Biology

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

Laura Novellasdemunt et al.

EMBO JOURNAL (2020)

Review Gastroenterology & Hepatology

Collagen biology and non-invasive biomarkers of liver fibrosis

Morten A. Karsdal et al.

LIVER INTERNATIONAL (2020)

Review Biochemistry & Molecular Biology

R-spondin-mediated WNT signaling potentiation in mammary and breast cancer development

Johanna M. Tocci et al.

IUBMB LIFE (2020)

Article Multidisciplinary Sciences

Tissue-targeted R-spondin mimetics for liver regeneration

Zhengjian Zhang et al.

SCIENTIFIC REPORTS (2020)

Review Oncology

Targeting the Wnt/β-catenin signaling pathway in cancer

Ya Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Review Biochemistry & Molecular Biology

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

Maurizio Parola et al.

MOLECULAR ASPECTS OF MEDICINE (2019)

Review Biochemistry & Molecular Biology

The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma

Jacopo Baglieri et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Gastroenterology & Hepatology

LGR4 protects hepatocytes from injury in mouse

Ziru Li et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2019)

Article Gastroenterology & Hepatology

R-spondin 2 Drives Liver Tumor Development in a Yes-Associated Protein-Dependent Manner

Caitlin B. Conboy et al.

HEPATOLOGY COMMUNICATIONS (2019)

Review Dentistry, Oral Surgery & Medicine

R-spondin signaling as a pivotal regulator of tissue development and homeostasis

Kenichi Nagano

JAPANESE DENTAL SCIENCE REVIEW (2019)

Review Oncology

Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?

R. G. Morgan et al.

BRITISH JOURNAL OF CANCER (2018)

Review Biochemistry & Molecular Biology

Liver fibrosis: Direct antifibrotic agents and targeted therapies

Detlef Schuppan et al.

MATRIX BIOLOGY (2018)

Article Biology

R-spondins can potentiate WNT signaling without LGRs

Andres M. Lebensohn et al.

Review Genetics & Heredity

Wnt Signalling in Gastrointestinal Epithelial Stem Cells

Dustin J. Flanagan et al.

Article Multidisciplinary Sciences

RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6

Emmanuelle Szenker-Ravi et al.

NATURE (2018)

Article Gastroenterology & Hepatology

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

Daniela Sia et al.

GASTROENTEROLOGY (2017)

Review Pharmacology & Pharmacy

The good and the bad collagens of fibrosis - Their role in signaling and organ function

M. A. Karsdal et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

Article Medicine, Research & Experimental

Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

Gabriele Picco et al.

EMBO MOLECULAR MEDICINE (2017)

Article Biochemistry & Molecular Biology

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

B. Madan et al.

ONCOGENE (2016)

Article Cell Biology

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size

Lara Planas-Paz et al.

NATURE CELL BIOLOGY (2016)

Editorial Material Cell Biology

Orchestrating Wnt signalling for metabolic liver zonation

Walter Birchmeier

NATURE CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds

Babita Madan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

N-Glycosylation of Human R-Spondin 1 Is Required for Efficient Secretion and Stability but Not for Its Heparin Binding Ability

Chiung-Fang Chang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Review Biochemistry & Molecular Biology

ZNRF3/RNF43-A direct linkage of extracellular recognition and E3 ligase activity to modulate cell surface signalling

Matthias Zebisch et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2015)

Article Cell Biology

The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation

Ana Sofia Rocha et al.

CELL REPORTS (2015)

Article Developmental Biology

Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3

Linda Cambier et al.

DEVELOPMENT (2014)

Article Gastroenterology & Hepatology

R-Spondin2 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis

Xinguang Yin et al.

DIGESTIVE DISEASES AND SCIENCES (2014)

Review Cell Biology

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

Wim de Lau et al.

GENES & DEVELOPMENT (2014)

Article Gastroenterology & Hepatology

Beta-Catenin Signaling in Murine Liver Zonation and Regeneration: A Wnt-Wnt Situation!

Jing Yang et al.

HEPATOLOGY (2014)

Article Gastroenterology & Hepatology

Stellate cells and the development of liver cancer: Therapeutic potential of targeting the stroma

Cedric Coulouarn et al.

JOURNAL OF HEPATOLOGY (2014)

Article Biochemistry & Molecular Biology

Regulation of the Follistatin Gene by RSPO-LGR4 Signaling via Activation of the WNT/β-Catenin Pathway in Skeletal Myogenesis

Xiang Hua Han et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

Review Cell Biology

Remodelling the extracellular matrix in development and disease

Caroline Bonnans et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

Helena C. Christianson et al.

MATRIX BIOLOGY (2014)

Article Multidisciplinary Sciences

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling

Kendra S. Carmon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Gastroenterology & Hepatology

Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury

Maryna Perepelyuk et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin

Yang Xie et al.

EMBO REPORTS (2013)

Article Cell Biology

The structural basis of R-spondin recognition by LGR5 and RNF43

Po-Han Chen et al.

GENES & DEVELOPMENT (2013)

Article Cell Biology

Structural basis for R-spondin recognition by LGR4/5/6 receptors

Dongli Wang et al.

GENES & DEVELOPMENT (2013)

Article Biochemistry & Molecular Biology

Crystal Structures of Lgr4 and Its Complex with R-Spondin1

Kai Xu et al.

STRUCTURE (2013)

Review Biochemistry & Molecular Biology

The R-spondin family of proteins: Emerging regulators of WNT signaling

Yong-Ri Jin et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

Article Multidisciplinary Sciences

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Huai-Xiang Hao et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

Andrei Glinka et al.

EMBO REPORTS (2011)

Review Gastroenterology & Hepatology

Hepatic Stellate Cells: Partners in Crime for Liver Metastases?

Ningling Kang et al.

HEPATOLOGY (2011)

Article Multidisciplinary Sciences

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling

Kendra S. Carmon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Cell Biology

Heparan Sulfate Proteoglycans

Stephane Sarrazin et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Article Oncology

Identification and validation of genes involved in gastric tumorigenesis

Thangarajan Rajkumar et al.

CANCER CELL INTERNATIONAL (2010)

Article Gastroenterology & Hepatology

Accelerated Liver Regeneration and Hepatocarcinogenesis in Mice Overexpressing Serine-45 Mutant β-Catenin

Kari N. Nejak-Bowen et al.

HEPATOLOGY (2010)

Article Oncology

A gene expression signature that defines breast cancer metastases

Rachel E. Ellsworth et al.

CLINICAL & EXPERIMENTAL METASTASIS (2009)

Article Gastroenterology & Hepatology

Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis

Changyong Li et al.

JOURNAL OF HEPATOLOGY (2009)

Article Developmental Biology

The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development

Olga Kazanskaya et al.

DEVELOPMENT (2008)

Article Developmental Biology

R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

Sheila M. Bell et al.

DEVELOPMENT (2008)

Article Biochemistry & Molecular Biology

R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling

Kazuma Tomizuka et al.

HUMAN MOLECULAR GENETICS (2008)

Article Dermatology

Mutations in R-Spondin 4 (RSPO4) underlie inherited anonychia

Yoshiyuki Ishii et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)

Article Developmental Biology

Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb

Ju-Suk Nam et al.

DEVELOPMENTAL BIOLOGY (2007)

Article Cell Biology

R-spondins in cutaneous biology - Nails and cancer

Diana C. Blaydon et al.

CELL CYCLE (2007)

Article Developmental Biology

R-spondin3 is required for mouse placental development

Motoko Aoki et al.

DEVELOPMENTAL BIOLOGY (2007)

Article Genetics & Heredity

R-spondin1 is essential in sex determination, skin differentiation and malignancy

Pietro Parma et al.

NATURE GENETICS (2006)

Article Biochemistry & Molecular Biology

F-spondin promotes nerve precursor differentiation

D Schubert et al.

JOURNAL OF NEUROCHEMISTRY (2006)

Article Immunology

Molecular aspects of regulation of collagen gene expression in fibrosis

RK Bhogal et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2005)