期刊
GELS
卷 8, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/gels8080461
关键词
fermented green tea waste extract gels; gel properties; oxidative damage; short-term; passive smoking
This study investigated the effects of fermented green tea waste extract gels (GTEG) on oxidative damage in mice exposed to short-term cigarette smoke. The experimental results showed that GTEG prepared with microbial transglutaminase had gel properties and strong biological activity and antioxidant properties. The passive smoking model mice exhibited inflammation and oxidative stress response, while the mice treated with GTEG showed increased body weight, antioxidant enzyme activity, and decreased levels of inflammatory factors.
Passive smoking is extensively studied because of its harmfulness to human health. In this study, the effects of fermented green tea waste extract gels (GTEG) on oxidative damage in mice exposed to short-term cigarette smoke (CS) were investigated. The GTEG is prepared from green tea waste extract and microbial transglutaminase (MTGase). The lung injury model of mice was established through passive smoking for 5 days. The experimental results revealed the following findings. (1) The GTEG induced by MTGase has obvious gel properties; (2) GTEG has strong biological activity and antioxidant properties in vitro; (3) The passive smoking model was established successfully; specifically, the lung tissue of the model mice exhibited inflammatory symptoms, oxidative stress response appeared in their bodies, and their inflammatory indicators increased; (4) Compared with the passive smoking model group, the mice, which were exposed to CS and received GTEG treatment, exhibited increased food intake and body weight; increased total superoxide dismutase and glutathione peroxidase activity in serum; significant decreases (p < 0.05) in the content levels of the inflammatory factors malondialdehyde, interleukin (IL)-6, and tumor necrosis factor alpha (TNF-alpha); and inhibited expression of IL-6, IL-33, TNF-alpha, and IL-1 beta inflammatory genes. The results indicated that taking GTEG can relieve the oxidative stress injury of mice caused by short-term CS and has antioxidant properties.
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