期刊
AMERICAN JOURNAL OF CHINESE MEDICINE
卷 50, 期 5, 页码 1299-1314出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X22500549
关键词
Adipose-Derived Stem Cells; Brain; Cortex; Curcumin; Rheumatoid Arthritis; Neuroprotection
资金
- Tri-Service General Hospital [TSGH-D-110073]
- Ministry of Science and Technology [MOST 110-2314-B-303-006, MOST 106-2320-B-303004-MY3]
- Hualien Tzu Chi Hospital [TCRD110-80]
- China Medical University
- Asia University [CMU106-ASIA-02]
The transplantation of curcumin-pretreated adipose-derived stem cells (ADSCs) in a rheumatoid arthritis (RA) rat model showed reduced inflammation and apoptosis, indicating a synergistic effect in enhancing neuronal protection.
Neurodegenerative diseases have become increasingly prevalent in the aged population. Rheumatoid arthritis (RA) is an autoimmune disease that causes systemic inflammation, damaging the neurons. However, only a few treatment options can reduce RA-induced neurodegeneration. This study aimed to evaluate whether adipose-derived stem cells (ADSCs) pretreated with curcumin could ameliorate RA-induced neurodegenerative illness in an RA rat model. Wistar rats were randomly classified into the following four groups: control, RA, RA + ADSC (1 x 10(6) cells per rat), and RA + curcumin-pretreated ADSC (1 x 10(6) cells per rat). After treatment for two months, the effects were specifically evaluated in the brains collected from the rats. Our results demonstrated that the transplantation of curcumin-pretreated ADSCs substantially reduced inflammation and apoptosis in the cortices of RA rats compared to those of other groups. Thus, the combination of ADSCs and curcumin exerts a synergistic effect in enhancing neuronal protection in RA rats. In the future, this combination therapeutic strategy can potentially be used as a novel treatment method to reduce RA-induced neurodegenerative disorders.
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