Mix-and-Match COVID-19 Vaccinations (Heterologous Boost): A Review

Various safe and effective COVID-19 vaccines utilizing different platforms (mRNA, adenovirus vector, inactivated virus-based) are available against SARS-CoV-2 infection. A prime-boost regimen (administration of two doses) is recommended to induce an adequate and sustained immune response. Most of these vaccines follow a homologous regimen (the same type of vaccine as priming and booster doses). However, there is a growing interest in a heterologous prime-boost vaccination regimen to potentially help address concerns posed by fluctuating vaccine supplies, serious adverse effects (anaphylaxis and thromboembolic episodes following adenovirus-based vaccines), new emerging virulent strains, inadequate immune response in immunocompromised individuals, and waning immunity. Various studies have demonstrated that heterologous prime-boost vaccination may induce comparable or higher antibody (spike protein) titers and a similar reactogenicity profile to the homologous prime-boost regimen. Based on these considerations, the Center for Disease Control and Prevention has issued guidance supporting the mix-and-match heterologous boost COVID-19 vaccine strategy.

Automated summary

Various safe and effective COVID-19 vaccines are available, and a prime-boost vaccination regimen is recommended. Heterologous prime-boost vaccination may provide comparable immune response and address concerns such as vaccine supply, adverse effects, emerging strains, inadequate response in immunocompromised individuals, and waning immunity.