期刊
BIOENGINEERING-BASEL
卷 9, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/bioengineering9080408
关键词
spinal column; pathological lumbar spine segment; SSM; PCA; biomechanics
This study aimed to develop a probabilistic atlas of the lumbar spine segment using statistical shape modeling and explore the variability of spine geometry using principal component analysis. The results showed that the principal shape modes were associated with specific morphological features of the spine segment, which can contribute to the development of new treatments for spine disorders.
The spine is the load-bearing structure of human beings and may present several disorders, with low back pain the most frequent problem during human life. Signs of a spine disorder or disease vary depending on the location and type of the spine condition. Therefore, we aim to develop a probabilistic atlas of the lumbar spine segment using statistical shape modeling (SSM) and then explore the variability of spine geometry using principal component analysis (PCA). Using computed tomography (CT), the human spine was reconstructed for 24 patients with spine disorders and then the mean shape was deformed upon specific boundaries (e.g., by +/- 3 or +/- 1.5 standard deviation). Results demonstrated that principal shape modes are associated with specific morphological features of the spine segment such as Cobb's angle, lordosis degree, spine width and height. The lumbar spine atlas here developed has evinced the potential of SSM to investigate the association between shape and morphological parameters, with the goal of developing new treatments for the management of patients with spine disorders.
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