Antroxazole A, an oxazole-containing chamigrane dimer from the fungus Antrodiella albocinnamomea with immunosuppressive activity

Antroxazole A (1), a chamigrane type sesquiterpene dimer containing an oxazole moiety, has been characterized from cultures of the fungus Antrodiella albocinnamomea. The structure with absolute configuration was determined by extensive spectroscopic methods and single crystal X-ray diffraction. A plausible biosynthetic pathway for 1 was proposed. Compound 1 exhibits inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with an IC50 value of 16.3 mu M.

Automated summary

Antroxazole A (1), a chamigrane type sesquiterpene dimer containing an oxazole moiety, was isolated from cultures of the fungus Antrodiella albocinnamomea. It exhibited specific inhibition against LPS-induced proliferation of B lymphocyte cells.