4.5 Article

The association between small airway dysfunction and aging: a cross-sectional analysis from the ECOPD cohort

期刊

RESPIRATORY RESEARCH
卷 23, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12931-022-02148-w

关键词

Small airway dysfunction; Aging; Computed tomography; Impulse oscillometry; Spirometry

资金

  1. Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01S155]
  2. Nature Key Research and Development Program [2016YFC1304101]
  3. National Science Foundation of China [81970045]
  4. Zhong Nanshan Medical Development Foundation of Guangdong Province [ZNSA-2020003, ZNSA-2020012, ZNSA-2020013]
  5. Guangdong Natural Science Foundation [2018A0303130227]
  6. Science and Technology Program of Guangzhou [201904010071]
  7. State Key Laboratory of Respiratory Disease [SKLRD-QN-201913]

向作者/读者索取更多资源

This study comprehensively assessed the relationship between aging and SAD using computed tomography, impulse oscillometry, and spirometry perspectives.
Background Aging has been evidenced to bring about some structural and functional lung changes, especially in COPD. However, whether aging affects SAD, a possible precursor of COPD, has not been well characterized. Objective We aimed to comprehensively assess the relationship between aging and SAD from computed tomography, impulse oscillometry, and spirometry perspectives in Chinese. Methods We included 1859 participants from ECOPD, and used a linear-by-linear association test for evaluating the prevalence of SAD across various age subgroups, and multivariate regression models for determining the impact of age on the risk and severity of SAD. We then repeated the analyses in these subjects stratified by airflow limitation. Results The prevalence of SAD increases over aging regardless of definitional methods. After adjustment for other confounding factors, per 10-yrs increase in age was significantly associated with the risk of CT-defined SAD (OR 2.57, 95% CI 2.13 to 3.10) and the increase in the severity of air trapping (beta 2.09, 95% CI - 0.06 to 4.25 for LAA(-856)), airway reactance (beta - 0.02, 95% CI - 0.04 to - 0.01 for X5; beta 0.30, 95% CI 0.13 to 0.47 for AX; beta 1.75, 95% CI 0.85 to 2.66 for Fres), as well as the decrease in expiratory flow rates (beta - 3.95, 95% CI - 6.19 to - 1.71 for MMEF%predicted; beta - 5.42, 95% CI - 7.88 to - 2.95 for FEF50%predicted) for SAD. All these associations were generally maintained in SAD defined by IOS or spirometry. After stratification of airflow limitation, we further found that the effect of age on LAA(-856) was the most significant among almost all subgroups. Conclusions Aging is significantly associated with the prevalence, increased risk, as well as worse severity of SAD. CT may be a more optimal measure to assess aging-related SAD. The molecular mechanisms for the role of aging in SAD need to be explored in the future. Trialregistration Chinese Clinical Trial Registry ChiCTR1900024643. Registered on 19 July 2019

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据