4.2 Article

A large deletion encompassing exon 2 of the ectodysplasin A (EDA) gene in a British blue crossbred calf with hypohidrotic ectodermal dysplasia

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X-Linked Hypohidrotic Ectodermal Dysplasia in Crossbred Beef Cattle Due to a Large Deletion in EDA

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Summary: The article describes a case of ECTD1-like syndrome in five Red Angus-Simmental bull calves born over a six-year period in a herd in the Western United States. The calves exhibited severe hypotrichosis and oligodontia. Skin histopathology revealed small-caliber hair follicles with a slightly higher density in the affected animals. Whole-genome sequencing identified a deletion involving part of the EDA gene, which is likely the cause of this genetic skin disorder.

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