Self-assemblies with cascade effect to boost antitumor systemic immunotherapy

Bio-organic hybrid self-assemblies based on amino acids, conjugated polymers, Fe3+ and enzymes are fabricated with tumor environment-responsive and light-triggered NO release properties. By sequential energy consumption, NO attack and immune activation, FFPG shows boosted antitumor activity toward both primary and distant tumors. The three-level cascade strategy (starvation/NO/immunotherapy) adopted in this work offers a pathway to address the dilemma of low cure rate of malignant tumors.

Automated summary

Bio-organic hybrid self-assemblies with tumor environment-responsive and light-triggered NO release properties are fabricated. These self-assemblies show boosted antitumor activity by sequential energy consumption, NO attack, and immune activation, offering a new pathway to address the low cure rate of malignant tumors.