Photocatalyst-free hydroacylations of electron-poor alkenes and enones under visible-light irradiation

Herein we present a photocatalyst- and additive-free radical hydroacylation of electron-poor double bonds under mild reaction conditions. Using 4-acyl-Hantzsch ester radical reservoirs, various Michael acceptors, enones and para-quinone methide substrates could be used. The protocol enabled further derivatizations and it could also be extended to a few unactivated alkenes. Moreover, the nature of the radical process was also investigated.

Automated summary

We have successfully developed a photocatalyst- and additive-free radical hydroacylation reaction under mild reaction conditions. By utilizing 4-acyl-Hantzsch ester radical reservoirs, various substrates including Michael acceptors, enones, and para-quinone methides can be reacted. This protocol allows for further derivatizations and can also be extended to unactivated alkenes. Furthermore, the nature of the radical process has been investigated.