期刊
BIOANALYSIS
卷 14, 期 14, 页码 1005-1020出版社
FUTURE SCI LTD
DOI: 10.4155/bio-2022-0100
关键词
baicalein; bioanalytical method; HPLC; paclitaxel; simultaneous quantification
资金
- Department of Science and Technology (DST), New Delhi, India [DST/INSPIRE/03/2017/001474/IF170832]
A novel HPLC method has been developed and validated for simultaneous estimation of paclitaxel and baicalein. The method showed a wide linear range and low limits of quantification. According to international guidelines, the method is precise and accurate, suitable for formulation development and bioanalytical studies.
Aim: A novel HPLC method was developed and validated for the simultaneous estimation of paclitaxel (PTX) and baicalein (BAC). Materials & methods: The analytes were resolved in a C18 column using the aqueous solution of formic acid (0.10% v/v) and MeOH (30:70 v/v). Results: The developed method was found to be linear over the concentration ranges 0.039-10 mu g/ml and 0.019-10 mu g/ml for PTX and BAC, respectively. The lower limits of quantification obtained were 0.042 mu g/ml and 0.361 mu g/ml for PTX and BAC, respectively. Conclusion: The developed method was found to be precise and accurate as per the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use guidelines, for simultaneous estimation of PTX and BAC, having an application in formulation development and bioanalytical studies.
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