期刊
APPLIED SCIENCES-BASEL
卷 6, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/app6010008
关键词
synthesis; antitumour; thiazole; amide
类别
资金
- National Natural Science Foundation of China [21102103, 31401691]
- China Postdoctoral Science Foundation [2014T70222]
- Zhejiang Provincial Science Foundation of China [LY16C140007, LQ13B020003]
- National Natural Science Foundation of China [21102103, 31401691]
- China Postdoctoral Science Foundation [2014T70222]
- Zhejiang Provincial Science Foundation of China [LY16C140007, LQ13B020003]
A series of novel 2-phenyl-4-trifluoromethyl thiazole-5-carboxamide derivatives have been synthesized and evaluated for their anticancer activity against A-549, Bel7402, and HCT-8 cell lines. Among the tested compounds, highest activity (48%) was achieved with the 4-chloro-2-methylphenyl amido substituted thiazole containing the 2-chlorophenyl group on the two position of the heterocyclic ring. Other structurally similar compounds displayed moderate activity. The key intermediates have been fully characterized.
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