期刊
ANNUAL REVIEW OF VIROLOGY, VOL 3
卷 3, 期 -, 页码 29-51出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-virology-110615-035556
关键词
retrovirus; RNA tumor virus; HIV; murine leukemia virus; Rous sarcoma virus; Howard Temin; David Baltimore
类别
资金
- NCI NIH HHS [R35 CA200421, R01 CA089441] Funding Source: Medline
In 1970 the independent and simultaneous discovery of reverse transcriptase in retroviruses (then RNA tumor viruses) by David Baltimore and Howard Temin revolutionized molecular biology and laid the foundations for retro-virology and cancer biology. In this historical review we describe the formulation of the controversial provirus hypothesis by Temin, which ultimately was proven by his discovery of reverse transcriptase in Rous sarcoma virus virions. Baltimore arrived at the same discovery through his studies on replication of RNA-containing viruses, starting with poliovirus and then moving to vesicular stomatitis virus, where he discovered a virion RNA polymerase. Subsequent studies of reverse transcriptase led to the elucidation of the mechanism of retrovirus replication, the discovery of oncogenes, the advent of molecular cloning, the search for human cancer viruses, and the discovery and treatment of HIV/AIDS.
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