期刊
ANNUAL REVIEW OF VIROLOGY, VOL 3
卷 3, 期 -, 页码 533-553出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-virology-110615-042435
关键词
virus; cell death; apoptosis; necroptosis; pyroptosis
类别
资金
- NIAID NIH HHS [R01 AI110637] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI110637] Funding Source: NIH RePORTER
Cell death is a common outcome of virus infection. In some cases, cell death curbs virus replication. In others, cell death enhances virus dissemination and contributes to tissue injury, exacerbating viral disease. Three forms of cell death are observed following virus infection-apoptosis, necroptosis, and pyroptosis. In this review, I describe the core machinery needed for each of these forms of cell death. Using representative viruses, I highlight how distinct stages of virus replication initiate signaling pathways that elicit these forms of cell death. I also discuss viral strategies to overcome the deleterious effects of cell death on virus propagation and the consequences of cell death for host physiology.
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