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Protocol for the generation of HIV-1 genomic RNA with altered levels of N6-methyladenosine

STAR PROTOCOLS (2022)

N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages

Shuliang Chen et al.

Summary: This study highlights the role of m(6)A modifications of HIV-1 RNA in suppressing IFN-I expression in myeloid cells, with the cellular protein RIG-I contributing to innate sensing of m(6)A-defective HIV-1 RNA. Modulation of m(6)A levels in HIV-1 RNA alters the innate immune responses in myeloid cells, suggesting an evasion mechanism of innate immune sensing by m(6)A modifications.

PLOS PATHOGENS (2021)

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Article Immunology

m6A modification controls the innate immune response to infection by targeting type I interferons

Roni Winkler et al.

NATURE IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Differential m(6)A, m(6)A(m), and m(1)A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

Jiangbo Wei et al.

MOLECULAR CELL (2018)

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Article Biochemistry & Molecular Biology

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

Guanqun Zheng et al.

MOLECULAR CELL (2013)

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Protocol for the generation of HIV-1 genomic RNA with altered levels of N6-methyladenosine

相关参考文献

N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages

m6A modification controls the innate immune response to infection by targeting type I interferons

Differential m(6)A, m(6)A(m), and m(1)A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

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