☆ 4.7 Letter

Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Exploiting senescence for the treatment of cancer

Liqin Wang et al.

Summary: This review discusses how senescence can be induced in cancer cells and how the distinctive features of senescent cancer cells can be exploited for selective eradication. It also explores activation of the host immune system as an attractive way to clear senescent cancer cells, and the potential benefits of a sequential treatment approach with pro-senescence therapy followed by senolytic therapy.

NATURE REVIEWS CANCER (2022)

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Review Cell Biology