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Article
Chemistry, Multidisciplinary
Yuxin Xing et al.
Summary: Utilizing a novel morphology fragmentation strategy, flower-like SAC nanozymes were fabricated with improved 3D accessibility of active sites, enhancing ROS generation and biomolecule damage. This approach opens up new avenues for ROS therapy by promoting re-sensitization of drug-resistant tumors.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Daoming Zhu et al.
Summary: A light-controlled oxidative stress amplifier system is designed in this study, showing synergistic antitumor activity in solid tumors. The system self-produces H2O2 and transforms cold tumors, and the combination of photothermal therapy, chemotherapy, and nanozyme-based catalytic therapy further enhances tumor immunogenic death and antitumor immunity.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Bolong Xu et al.
Summary: Single-atom nanozymes are a new research frontier in the biomedical fields. A melamine-mediated pyrolysis activation strategy has been used to controllably fabricate iron-based SAzymes with a five-coordinated structure (FeN5). The FeN5 SAzyme shows excellent peroxidase-like activity and significantly enhanced antitumor effect in vitro and in vivo.
ADVANCED MATERIALS
(2022)
Article
Biochemical Research Methods
Liping Sun et al.
Summary: Biothiol detection is crucial for clinical disease diagnosis. Previous nanozyme-based colorimetric sensors showed unsatisfactory catalytic activity, leading to high detection limits. Hence, it is necessary to develop new nanozymes with high catalytic activity for biothiol detection. This study explores Co-N-C SAzymes with high oxidase-like activity for colorimetric detection of biothiols, demonstrating high sensitivity and selectivity. It offers new insights for biosensing using Co-N-C SAzymes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Biomedical
Huan He et al.
Summary: This study developed a bioadhesive injectable hydrogel for localized immune modulation and catalytic immunotherapy in cancer treatment. The hydrogel containing a nanozyme and immune adjuvant effectively targeted the tumor microenvironment while limiting systemic exposure and enhancing therapeutic efficacy.
Article
Engineering, Biomedical
Yutian Su et al.
Summary: Nanozyme-based catalytic therapy plays an important role in tumor therapy by generating lethal reactive oxygen species. However, most nanozymes have mono catalytic performances in the tumor microenvironment, which lowers their therapeutic efficiency. In this study, a newly-developed nanozyme with dual enzyme-mimic catalytic activity is designed, which can achieve an enhanced nanocatalytic therapy effect through photothermal augmentation.
Article
Engineering, Environmental
Yaofang Fan et al.
Summary: SA-Pt/g-C3N4-K nanozyme exhibits peroxidase-like activity for antibiotic detection and antibacterial applications. Experimental results and density functional theory calculations show that the Pt-N-C structure can significantly enhance center dot OH generation by reducing the desorption energy of OH* from the active site.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Youyou Feng et al.
Summary: The combination of mesoporous Fe-N-C SAzyme with photothermal treatment enhances the catalytic performance, resulting in a more effective antibacterial treatment compared to using single antibacterial methods.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Engineering, Environmental
Qiumeng Chen et al.
Summary: The study introduced a Fe-Bi bimetallic MOF-derived single-atom nanozyme, FeBi-NC, with dual metal-Nx catalytic sites for pollution remediation. FeBi-NC showed high oxidase mimicking activity and was used for sensitive screening of AChE activity, demonstrating strong peroxymonosulfate activation capability for rapid degradation of rhodamine B. The high activity of FeBi-NC is attributed to the isolated Fe-N-4 and Bi-N-4 sites and their synergy.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yuan Chen et al.
Summary: This study presents a single-atom nanozyme Cu SAs/CN with APX-like behavior, showing comparable activity and kinetics to natural APXs. Through density functional theory, the Cu-N-4 moieties in the active center of Cu SAs/CN are determined to facilitate the activation and cleavage of H2O2 molecules, resulting in fast kinetics.
Article
Nanoscience & Nanotechnology
Pengyuan Qi et al.
Summary: In this study, a novel platelet membrane-coated mesoporous Fe single-atom nanozyme (PMS) was developed for efficient tumor therapy. The PMS showed satisfactory NIR-II photothermal performance, high peroxidase activity, good tumor-targeting ability, and the ability to serve as a carrier for protein drugs. In vitro and in vivo experiments demonstrated the PMS's ability to inhibit HSP expression and effectively accumulate in tumor sites without causing significant toxicity in major organs. This study provides a new promising approach for cancer treatment using biomimetic mesoporous Fe single-atom nanozymes.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Hui Wang et al.
Summary: This study presents the construction of biocompatible and trackable-imaging single-atom nanozymes (SAzymes) with efficient catalytic activities. The enzyme-like activity was enhanced by tenfold by varying the calcination conditions. Moreover, the Co/TiO2 SAzymes exhibited good intrinsic biocompatibility and excellent tolerance toward the biological medium, while the hollow structure facilitated the loading of drugs and imaging agents for image-guided chemo-chemodynamic therapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Chong-Bo Ma et al.
Summary: This study presents a facile synthetic strategy for a dual single-atom nanozyme composed of zinc (Zn) and molybdenum (Mo). The nanozyme utilizes polyoxometalates and supramolecular coordination complexes as metal-atom precursors, and an amphiphilic aerogel as the supporting substrate. The dual single-atoms of Zn and Mo exhibit a synergistic effect and peroxidase-like activity. The nanozyme shows outstanding stability and is capable of detecting various analytes in different samples.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Environmental
Yi Yu et al.
Summary: This study prepares an injectable ointment based on MOF-based single-atom catalysis systems, which exhibits high anti-biofilm activity and provides a rapid, effective, non-invasive, and convenient strategy for the treatment of periodontitis without antibiotics. The ointment shows superior therapeutic effectiveness compared to the clinically used Periocline.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Physical
Peng Zhu et al.
Summary: Hydrogen production from water splitting using renewable electric energy is a key topic for achieving a carbon neutral future. Single atom catalysts (SACs) have emerged as a new frontier in catalysis, particularly in the hydrogen evolution reaction (HER), due to their high activity and excellent chemical selectivity. However, the influence of the neighboring coordinated atoms from the supports is often neglected in the classification of SACs. This review proposes a new classification method based on the type of supports and highlights the importance of the metal-support interaction and coordination environment. Structural designing strategies are also proposed to address the current challenges in SACs for HER.
Review
Chemistry, Physical
Xiaobo Zheng et al.
Summary: This review comprehensively outlines the recent exciting advances on novel atomically dispersed metal catalysts (NADMCs) with emphasis on understanding the synergistic interactions among multiple metal atoms and underlying structure-performance relationships. It discusses the synthetic approaches, characterizations, and energy-related applications of NADMCs, and provides insights into the remaining challenges and opportunities for their development.
Article
Chemistry, Multidisciplinary
Mengyan Zhao et al.
Summary: This study presents a dual-active site monodisperse catalyst that can generate tumor-related reactive oxygen species and achieve highly efficient tumor therapy through synergistic catalytic reactions. In vitro and in vivo experiments demonstrate that this catalyst can effectively induce cell apoptosis and inhibit tumor growth with low metal concentrations and high therapeutic effects.
Article
Biophysics
Min Feng et al.
Summary: In this study, highly active single-atom nanozymes (SAzymes) were designed and realized for the first time, and a novel colorimetric method for detecting PPD in hair dyes was developed based on their peroxidase-like activity.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Ting Pan et al.
Summary: A novel nanozyme CS@Fe/CDs was designed to combat bacterial biofilms. Through the peroxidase-like catalytic activity and antibacterial activity of CS, CS@Fe/CDs effectively cleaved extracellular DNA and caused cell death within bacterial biofilms. This approach shows great potential in managing bacterial biofilm fouling in food safety and environmental protection.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Physical
Runze Li et al.
Summary: This article discusses the key factors affecting the catalytic performance of metal-based atomically dispersed catalysts and their relationship with the active sites. It first introduces the effectiveness of active site design through coordination effects, then discusses the role of chemical bonds in the active sites and the influence of the spacing of active atoms in intermetallic compounds on catalytic behavior. Additionally, the importance of synergistic effects in catalyst design is emphasized, and the key parameters affecting catalytic performance at the atomic scale are summarized.
Article
Environmental Sciences
Rui Li et al.
Summary: In this study, nitrogen and sulfur coordinated Fe-N/S-C SAzymes were synthesized using peanut shells as carbon, nitrogen, and sulfur source. The SAzymes showed high oxidase-like activities due to doping of sulfur, and this property was further confirmed by density functional theory calculations. A novel on-off-on colorimetric sensor was developed based on the SAzymes for simultaneous detection of GSH and Hg2+, with good analytical performance in real samples.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Applied
Hong Li et al.
Summary: We developed a simple method for specific determination of propyl gallate and formaldehyde using single-atom nanozymes. The nanozymes, based on zinc-nitrogen-carbon and loaded with hemin, exhibited peroxidase-like activity and could catalyze the oxidation of propyl gallate. A colorimetric sensor based on the nanozymes was also developed for rapid analysis of propyl gallate and formaldehyde in food samples.
Article
Chemistry, Applied
Guangchun Song et al.
Summary: Single-atom nanozymes exhibit attractive enzyme-like activities, particularly phosphatase-like activity. The combination of Al3+ and the O atom in its structure can inhibit its enzyme activity. A fluorescent sensor for detecting Al3+ was constructed based on single-atom nanozymes, enabling fast and efficient detection.
Article
Chemistry, Multidisciplinary
Weiwei Wu et al.
Summary: This article investigates the inhibitory effect of nanozymes and the advantages of single-atom Fe-N-C nanozymes in mechanism research. The study finds that a common analgesic-antipyretic drug inhibits the oxidase-like activity of Fe-SANs in a reversible mixed-inhibition manner. Additionally, a calorimetric method for drug detection based on nanozyme inhibition is proposed.
Article
Engineering, Environmental
Yamei Lin et al.
Summary: A novel nitrogen-doped carbon material Fe1@CN20 was developed as a laccase mimic, offering better stability and recyclability, and showing more sensitive performance in the detection and degradation of phenolic compounds.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Qiaolan Shi et al.
Summary: The development of single-atom catalysts (SACs) in biomedical applications is a rapidly growing field, focusing on understanding the interactions between metal atoms and support materials as well as classifying various enzyme-like activities. This interdisciplinary knowledge integration helps drive the development of SACs in biomedicine.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Liping Sun et al.
Summary: The study focuses on enhancing the aqueous dispersion and recognition ability of SAzymes by engineering DNA onto them, offering new insights for their application in bioanalysis. By studying the interactions between Fe-N-C SAzymes and DNA, it was found that adenine and thymine had higher adsorption affinity on Fe-N-C SAzymes.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Multidisciplinary
Yiran Ying et al.
Summary: Double-atom catalysts (DACs) have emerged as a novel frontier in heterogeneous catalysis, showing improved catalytic activity through synergistic effects while maintaining high atomic utilization efficiency, good selectivity, and stability. Current research focuses on the design, experimental and theoretical progress, and practical applications of DACs in various catalytic reactions.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Haile Liu et al.
Summary: Clusterzymes based on Au-25 clusters exhibit high catalytic activity and selectivity in enzyme-mimicking reactions, such as GPx-like, CAT-like, and SOD-like activities. They can effectively decrease oxidative stress and inflammation in injured brain, showing promise in mitigating neuroinflammation.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yang Zhu et al.
Summary: The Mn/PSAE constructed here demonstrates significant catalytic activity in weakly acidic tumor environments, which enables the generation of sufficient reactive oxygen species (ROS) through a series of cascade reactions to effectively kill tumor cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Yuanjun Chen et al.
Summary: A novel and efficient strategy was reported to access high-performance nanozymes by atomizing platinum nanoparticles into single atoms, leading to dramatically enhanced enzymatic performance. The engineered single-atom Pt nanozyme exhibited remarkable catalytic activity and kinetics, far exceeding traditional Pt nanoparticle nanozymes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Daji Wang et al.
Summary: The outbreak of SARS-coronavirus 2 has become a global health emergency, with no effective treatment available. A TiO2 supported single-atom nanozyme containing atomically dispersed Ag atoms, Ag-TiO2 SAN, has high adsorption of SARS-CoV2 pseudovirus and shows promising antiviral effects.
Article
Chemistry, Multidisciplinary
Mengyu Chang et al.
Summary: Photothermal therapy (PTT) is a promising tumor therapeutic modality, but minimizing damage to healthy tissues while maximizing efficiency is crucial. Utilizing a single-atom nanozyme (SAzyme) can improve the effectiveness of mild PTT by promoting ferroptosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Environmental
Yu Mao et al.
Summary: The article introduces a colorimetric sensing method for Cr(VI) based on single-atom nanozymes, achieving detection through specific interactions, with high sensitivity and selectivity, and successful application in Cr(VI) detection in water and food samples.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Biomedical
Xianwen Wang et al.
Summary: This study highlights the enhanced catalytic activity of nanozymes through the construction of Cu SASs/NPC for photothermal-catalytic antibacterial treatment strategy. The introduction of Cu significantly improves the catalytic performance of nanozymes, effectively killing bacteria and improving sterilization effect. The synergistic PTT-catalytic antibacterial strategy shows almost 100% antibacterial efficiency against E. coli and MRSA, demonstrating wide bio-applications of Cu-containing catalysts in antibacterial and anti-infective treatments.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Physical
Shufang Ji et al.
Summary: By precisely controlling the electronic structure of the single-atom iron active center, FeN3P-SAzyme exhibits catalytic activity and kinetics comparable to natural enzymes, showing promising potential as an effective therapeutic strategy for inhibiting tumor cell growth.
Article
Nanoscience & Nanotechnology
Wenyu Wang et al.
Summary: This study successfully constructed Ru single-atom enzymes with superior activity and stability by using carbon dots as the carrier material, leading to a lethal effect on cancer cells. The Ru single-atom enzymes exhibit excellent peroxidase-like activity, activating H2O2 to produce reactive oxygen species that cause damage to cancer cells.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Yifeng Chen et al.
Summary: In this study, highly active POD-like nanozymes were synthesized by loading Pt clusters on Fe single-atom nanozymes, exhibiting remarkable enzyme-like activities. The cascade signal amplification strategy based on these nanozymes showed excellent sensitivity and selectivity in biosensing applications.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Weiqing Xu et al.
Summary: The study designed a coordination structure of Fe-N-C single-atom catalysts, with the axial ligand-engineered NG-Heme showing superior enzyme-like activity, vividly mimicking the active sites of peroxidase and being applicable in clinical sample analysis.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yong Liu et al.
Summary: This study presents a multifunctional single-atom catalytic sites (SACs) type for enhanced cancer treatment, with the ability to selectively release drugs and induce tumor-specific Fenton reactions in the tumor microenvironment. The nanoagent modified with cell membrane demonstrates better in vivo therapeutic performance, breaking through the limitations of single-pathway therapy by combining chemodynamic therapy and chemotherapy.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Analytical
Hongye Yan et al.
Summary: The study synthesized single-atom Bi-anchored Au hydrogels to precisely regulate nanozyme activity and specificity at the atomic scale, achieving a deeper understanding of their catalytic nature. By introducing single Bi atoms, the POD-like activity was significantly enhanced, while having negligible effects on other closely related redox enzyme activities.
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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Dongdong Wang et al.
NATURE COMMUNICATIONS
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ANALYTICA CHIMICA ACTA
(2020)
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Zhaoyuan Lyu et al.
Review
Materials Science, Biomaterials
Jiahui Pei et al.
BIOMATERIALS SCIENCE
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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ANALYTICAL CHEMISTRY
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CHINESE JOURNAL OF CATALYSIS
(2018)
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CHEMISTRY-AN ASIAN JOURNAL
(2016)
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Arun Prakash Periasamy et al.
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Editorial Material
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NATURE NANOTECHNOLOGY
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