期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.971674
关键词
oncolytic virus; IFN; signaling; oncology; tumor; cancer; immunology
类别
资金
- Scientific research project of Tianjin Education Commission
- National Natural Science Foundation of China
- Science and Technology Program of Tianjin
- [2021KJ134]
- [81973728]
- [21ZYJDJC00070]
This review focuses on the regulatory mechanisms of interferons (IFNs) by various oncolytic viruses and their combination therapies. Understanding these mechanisms is of great significance for improving the antitumor effect of oncolytic viruses.
Various studies are being conducted on oncolytic virotherapy which one of the mechanisms is mediating interferon (IFN) production by it exerts antitumor effects. The antiviral effect of IFN itself has a negative impact on the inhibition of oncolytic virus or tumor eradication. Therefore, it is very critical to understand the mechanism of IFN regulation by oncolytic viruses, and to define its mechanism is of great significance for improving the antitumor effect of oncolytic viruses. This review focuses on the regulatory mechanisms of IFNs by various oncolytic viruses and their combination therapies. In addition, the exerting and the producing pathways of IFNs are briefly summarized, and some current issues are put forward.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据