期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 10, 期 39, 页码 8013-8023出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2tb01671k
关键词
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资金
- Six Talent Peaks Project in Jiangsu Province [SWYY-060]
- Projects of Nanjing Normal University [184080H20192, 184080H10386, 184080H202B283]
This study presents a layer-by-layer strategy for the construction of a dual-functional coating on silicone rubber substrates, which possesses both antifouling and bactericidal properties. The optimal copolymer composition of 70% SBMA and 30% NHSMA exhibited a highly efficient overall antibacterial property with near 100% antibacterial ratio without compromising cellular viability. This strategy can be applied to various silicone rubber-based biomedical devices requiring antibacterial surfaces.
Biofilm formation on biomedical devices is a major cause of device-associated infection. Traditional antibiotic treatment for biofilm-associated infection increases the risk of multidrug resistance. Thus, there is an urgent need to develop antibiotic-free strategies to prevent biofilm formation on biomedical devices. Herein, we report a layer-by-layer strategy to construct an antifouling and bactericidal dual-functional coating for silicone rubber (SR)-based substrates. Five zwitterionic active ester copolymers, p(SBMA-co-NHSMA), with varied zwitterionic pSBMA components that ranged from 50 to 90% (molar ratio) were precisely prepared. Based on -NH2/NHS chemistry, a zwitterionic pSBMA antifouling coating was successfully constructed on an -NH2-activated SR surface, while a biguanide polymer (PHMB) bactericidal coating was consequently tethered. The relationship between the composition of the polymeric coating and the overall antibacterial property (antifouling and bactericidal) that was endowed to the SR surface was established. The in vitro and in vivo results consistently showed that the optimal p(SBMA-co-NHSMA) copolymer (SBMA/NHSMA with molar percentage of 70/30) synergistically utilized antifouling and bactericidal abilities to endow a highly efficient overall antibacterial property (near 100% antibacterial ratios) to SR70-PHMB substrates without compromising cellular viability. This strategy may be applied to the many SR-based biomedical implants and devices where an antibacterial surface is required.
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