Recent Advances in Transition-Metal-Catalyzed C-H Activation of Pyridone/Isoquinolones

Pyridones/isoquinolones are a kind of important nitrogen-containing heterocyclic compounds, which have good biological activity and unique chemical properties, and play an important role in synthesis chemistry, functional materials, biomedicine and so on. Recently, transition-metal-catalyzed C-H activation has emerged as a more atom- and step-economical strategy for the construction of functionalized pyridones/isoquinolones, and it has attracted the attention of many organic chemists. Herein, the recent advances in transition-metal-catalyzed C-H activation of pyridone/isoquinolone derivatives are summarized according to the types of metal catalysis. An emphasis on the discussion of catalytic system, reaction mechanisms, substrate scopes and synthetic applications is also introduced. Finally, the limitations and development trend of this research field are analyzed and prospected.

Automated summary

This article summarizes the recent advances in transition-metal-catalyzed C-H activation of pyridone/isoquinolone derivatives, focusing on catalytic systems, reaction mechanisms, substrate scopes, and synthetic applications.