Directing group strategies in rhodium-catalyzed C-H amination

Construction of a carbon-nitrogen bond is one of the most prevalent operations in nature and organic synthesis. The resulting amino compounds are privileged structural fragments in natural products, pharmaceutical drugs, and functional materials. With the rapid advancement of C-H bond activation, directing-group strategies in C-H amination catalyzed by rhodium have emerged. This reaction approach considerably enhances the step economy and atom economy of the reaction, and it complies with green chemistry and atom economy. The reactivity and selectivity of chelation-assisted rhodium-catalyzed C-H amination are discussed in relation to the types of aminating reagent, as well as the challenges and future development prospects in this field.

Automated summary

Construction of a carbon-nitrogen bond is a common operation in nature and organic synthesis. Rhodium-catalyzed C-H amination with directing-group strategies improves the step economy and atom economy of the reaction, complying with green chemistry principles. The reactivity and selectivity of chelation-assisted rhodium-catalyzed C-H amination are discussed, along with the challenges and future prospects in this field.