期刊
BIOLOGICHESKIE MEMBRANY
卷 39, 期 3, 页码 163-171出版社
MEZHDUNARODNAYA KNIGA
DOI: 10.31857/S0233475522030094
关键词
blood coagulation; fibrinolysis; membrane reactions; scaffolds
类别
Blood coagulation and fibrinolysis systems play crucial roles in controlling the formation and dissolution of fibrin clots in blood plasma. These processes occur on specialized scaffolds, such as phospholipid membranes, fibrin and extracellular matrix protein complexes, and polymers containing phosphate groups. The physiological significance and physical meaning of these scaffolds vary, and their roles in hemostasis and thrombosis are still being studied.
Blood coagulation and fibrinolysis systems are enzymatic cascades in blood plasma that control the formation and dissolution of a fibrin clot, respectively. However, critical processes in both systems occur on specialized scaffolds but not in the liquid phase. These scaffolds are two- or three-dimensional matrices that provide special conditions for biochemical reactions. The following fundamental categories of scaffolds can be distinguished: (a) phospholipid membranes enriched with phosphatidylserine provided by a procoagulant subpopulation of activated platelets, as well as damaged endothelium; membranes of apoptotic bodies in atherosclerotic plaque; lipoproteins, and plasma microvesicles; (b) complex of fibrin and extracellular matrix proteins, which is associated with platelets and is the leading scaffold for pro- and anti-fibrinolytic processes; (c) polymers containing phosphate groups, including platelet polyphosphates and neutrophil extracellular traps. For some of these scaffolds, there are speculations about their physiological significance and physical meaning, while the role of others seems mysterious or at least pathophysiological. Herein we consider existing ideas about the roles and mechanisms of the involvement of these scaffolds in hemostasis and thrombosis.
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