期刊
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES
卷 72, 期 -, 页码 236-242出版社
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S2053273315022500
关键词
electron nanocrystallography; Timepix quantum area detector; carbamazepine; nicotinic acid; electron diffraction structure determination
资金
- Dutch Technology Foundation STW part of The Netherlands Organization for Scientific Research (NWO)
- Ministry of Economic Affairs
- Cyttron II, Leiden, The Netherlands
- European Union [312483 ESTEEM2]
Until recently, structure determination by transmission electron microscopy of beam-sensitive three-dimensional nanocrystals required electron diffraction tomography data collection at liquid-nitrogen temperature, in order to reduce radiation damage. Here it is shown that the novel Timepix detector combines a high dynamic range with a very high signal-to-noise ratio and single-electron sensitivity, enabling ab initio phasing of beam-sensitive organic compounds. Low-dose electron diffraction data (similar to 0.013 e(-) angstrom(-2) s(-1)) were collected at room temperature with the rotation method. It was ascertained that the data were of sufficient quality for structure solution using direct methods using software developed for X-ray crystallography (XDS, SHELX) and for electron crystallography (ADT3D/PETS, SIR2014).
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