期刊
CHINESE MEDICAL JOURNAL
卷 135, 期 12, 页码 1394-1403出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CM9.0000000000002235
关键词
Hematopoietic stem cell transplantation; Haploidentical; China
资金
- National Key Research and Development Program of China [2017YFA0105503]
- National Natural Science Foundation of China [82020108004]
- Natural Science Foundation of Chongqing Innovation Group [cstc2021jcyj-cxttX0001, 2020ZKZC02]
Hematopoietic stem cell transplantation is an effective medical procedure for treating hematological malignancies. China has made significant contributions to the global process of HSCT, with the haploid HSCT technology in the Beijing Protocol becoming the dominant choice in China. The development and refinement of HSCT techniques in China have had a global impact.
Hematopoietic stem cell transplantation (HSCT) is a highly effective and unique medical procedure for the treatment of most hematological malignancies. The first allogeneic transplantation was performed by E. Donnall Thomas in 1957. Since then, the field has evolved and expanded worldwide. The first successful allogenic HSCT (allo-HSCT) in China was conducted in 1981. Although the development of allo-HSCT in China lagged, China has since made considerable contributions to the process of HSCT worldwide, with more than 10,000 HSCTs performed annually. In particular, haploid HSCT (haplo-HSCT) technology represented in the Beijing Protocol has demonstrated similar efficacy to human leukocyte antigen-matched HSCT and has gradually become the pre-dominant choice for allo-HSCT in China. Currently, the number of haplo-HSCT procedures exceeds 5000 per year, and the Beijing Protocol has been greatly improved by implementing updated individualized strategies for controlling complications, relapse, and infection management. In addition, innovative haplo-HSCT technologies developed by different medical transplantation centers, such as Soochow, Zhejiang, Fujian, Chongqing, and Anhui, have emerged, providing inspiration for the refinement of global practice. This review will focus on the current activity in this field and highlight important trends that are vital in China's allo-HSCT process, examining the current viewpoint and future directions.
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