期刊
ORGANIC CHEMISTRY FRONTIERS
卷 9, 期 21, 页码 5912-5920出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo01323a
关键词
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资金
- NSFC [21772063]
- Open Project of State Key Laboratory for Supramolecular Structure and Materials [sklssm2022010]
An electrochemical trifluoromethylative cyclization of N-cyanamide alkenes and alkynes is reported, in which commercially available CF3SO2Na and readily available starting materials were used to assemble (bis)-C,N-trifluoromethylated cyclic amidines through a novel electrochemical and sustainable process. The reaction also provided a controllable access to trifluoromethylated azines and amides. Mechanism investigation and DFT calculations revealed the possible reaction pathway.
An electrochemical (bis)trifluoromethylative cyclization of N-cyanamide alkenes and alkynes is described, in which commercially available CF3SO2Na and readily available starting materials engaged in a novel electrochemical and sustainable process to assemble (bis)-C,N-trifluoromethylated cyclic amidines, which were previously inaccessible using known methods, with selective multiple bond formations in an undivided cell. Furthermore, this protocol also provided a rapid access to trifluoromethylated azines and amides in a controllable manner. A preliminary mechanism investigation and density functional theory (DFT) calculations were performed which revealed the possible reaction pathway.
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