Fast Initiating Furan-Containing Hoveyda-Type Complexes: Synthesis and Applications in Metathesis Reactions

Two new ruthenium complexes with chelating-ether benzylidene ligands bearing a furan moiety were synthesized and characterized, including X-ray crystallography. They initiated fast, also at 0 degrees C, and were found to be highly active in a variety of ring-closing, ene-yne, and cross-metathesis reactions, including an active pharmaceutical ingredient (API) model, which makes them good candidates for the transformation of complex polyfunctional compounds that require mild reaction conditions.

Automated summary

Two new ruthenium complexes with chelating-ether benzylidene ligands containing a furan moiety were synthesized and characterized. These complexes showed fast reactivity even at low temperatures and exhibited high activity in a variety of reactions, making them suitable candidates for the transformation of complex polyfunctional compounds that require mild reaction conditions.