On the evolution of coenzyme biosynthesis

Covering: up to 2022 The report provides a broad approach to deciphering the evolution of coenzyme biosynthetic pathways. Here, these various pathways are analyzed with respect to the coenzymes required for this purpose. Coenzymes whose biosynthesis relies on a large number of coenzyme-mediated reactions probably appeared on the scene at a later stage of biological evolution, whereas the biosyntheses of pyridoxal phosphate (PLP) and nicotinamide (NAD(+)) require little additional coenzymatic support and are therefore most likely very ancient biosynthetic pathways.

Automated summary

This report provides a comprehensive approach to understanding the evolution of coenzyme biosynthetic pathways. The analysis of various pathways reveals that coenzymes requiring a large number of coenzyme-mediated reactions likely appeared later in biological evolution, while the biosyntheses of pyridoxal phosphate (PLP) and nicotinamide (NAD(+)) are ancient pathways that require little additional coenzymatic support.