期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 3, 期 7, 页码 1283-1286出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.6b00503
关键词
cancer cells; gene transfection; biodegradable; highly branched poly(beta-amino ester)s; targeting
资金
- Science Foundation Ireland (SFI) [13/IA/1962, 14/TIDA/2367, 15/1FA/3037, 15/TIDA/2969]
- Health Research Board of Ireland [HRA-POR-2013-412]
- Doctoral Fund of Ministry of Education of China [RFDP-20130031110012]
- National Natural Science Foundation of China [20874052]
- University College Dublin
- Science Foundation Ireland (SFI) [15/TIDA/2969, 14/TIDA/2367] Funding Source: Science Foundation Ireland (SFI)
To enhance the gene transfection efficiency to targeted cells while reducing the side effects to untargeted cells is of great significance for clinical gene therapy. Here, biodegradable highly branched poly(beta-amino ester)s (HPAESS) are synthesized and functionalized with folate (HPAESSFA) and lactobionic acid (HPAESS-Lac) for targeted cancer cell gene transfection. Results show that because of the triggered degradability of the vector and enhanced receptor mediated cellular uptake of polyplexes, the HPAESS-FA and HPAESS-Lac exhibit superior gene transfection capability in specific cancer cells with negligible cytotoxicity, pointing to their promise as targeted vectors for efficient cancer gene therapy.
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