期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 3, 期 1, 页码 36-41出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.6b00573
关键词
gold nanoparticle; erythrocytes; fusion; drug delivery; CT-contrast
资金
- Nanotechnology Innovation Center of Kansas State (NICKS), Kansas State University, Manhattan, Kansas
- Johnson Cancer Research Center (JCRC), Kansas State University, Manhattan, Kansas
Red blood cells (RBCs) are the natural resident of the vascular lumen, therefore delivery of any agents within the vascular lumen could benefit by unique natural transporting features of RBCs. RBCs continuously circulate for 100 days before being sequestered in the spleen, they only extravasate at sites of vascular hemorrhage. Taking advantages of these features, we engineered RBC as a carrier in order to design a unique delivery system capable of delivering X-ray computed tomography (CT) contrast agents, gold nanoparticles (AuNPs), thereby acting as CT-contrast agent. A strategic membrane fusion technique was used to engineer the surface of RBC with gold nanoparticles in this in vitro study without altering its shape, size, and surface properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据