4.2 Article

Early OCTA Changes of Type 3 Macular Neovascularization Following Brolucizumab Intravitreal Injections

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Brolucizumab: A Newly Developed Anti-VEGF Molecule for the Treatment of Neovascular Age-Related Macular Degeneration

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Summary: This article reviews the unique molecular design of brolucizumab, a single-chain antibody fragment specifically designed for intraocular use, which allows for a higher concentration of material per intravitreal injection compared to other anti-VEGF agents. Clinical trials have shown the efficacy of brolucizumab in treating nAMD, with signals of a more durable treatment effect and the ability to be administered every 3 months to maintain disease control. The preclinical and clinical data provide evidence of sustained disease control with longer injection intervals, potentially reducing the treatment burden in nAMD patients.

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