期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 2, 期 7, 页码 1151-1161出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.6b00180
关键词
fucoidan; methacrylation; photo-cross-linking; marine biomaterials; tissue engineering; hydrogel
资金
- ERDF: Atlantic Area Project [2011-1/164 MARMED]
- ERDF: POCTEP Project [0687_NOVOMAR_1_P]
- FP7: Project POLARIS [FP7-REGPOT_CT2012-316331]
- Portuguese Foundation for Science and Technology (FCT) [EXPL/MAR-BIO/0165/2013, SFRH/BD/73172/2010, SFRH/BD/112139/2015, SFRH/BPD/85790/2012, SFRH/BPD/112140/2015]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/112139/2015, EXPL/MAR-BIO/0165/2013] Funding Source: FCT
Algae are abundant sources of bioactive components with extensive therapeutic properties, receiving much interest in recent years. The research on marine brown algae, namely one of its polysaccharide-fucoidan, has increased exponentially. Fucoidan is a sulfated cell-wall polysaccharide with several reported biological properties including anticancer, antivirus, anticoagulant, antioxidant and anti-inflammatory effects. In this study, fucoidan was functionalized by grafting methacrylic groups in the chain backbone, photo-cross-linkable under visible light to obtain biodegradable structures for tissue engineering. The functionalization reaction was carried out by concentrations (8 and 12%) of methacrylic anhydride (MA). The modified fucoidan (MFu) was characterized by FTIR and (HNMR)-H-1 spectroscopy to confirm the functionalization. Further, modified fucoidan was photo-cross-linked under visible light and using superhydrophobic surfaces, to obtain spherical particles with controlled geometries benefiting from the high repellence of the surfaces. When using higher concentrations of MA, the particles were observed to exhibit a smaller average diameter. Moreover, the behavior of L929 mouse fibroblast-like cells was evaluated when cultured in contact with photo-cross-linked particles was investigated, being observed up to 14 days in culture. The photo-cross-linking of MFu under visible light enables thus the formation of particles here suggested as potentially relevant in a wide range of biomedical applications.
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