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The role of secreted osteoclastogenic factor of activated T cells in bone remodeling

期刊

JAPANESE DENTAL SCIENCE REVIEW
卷 58, 期 -, 页码 227-232

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.jdsr.2072.07.001

关键词

Secreted osteoclastogenic factor of activated; T cells; Osteoclast; Bone remodeling; Bone resorption; Periodontal disease

资金

  1. Natural Science Foundation of Hubei Province of China [2019CFB688, 2021CFB056]
  2. National Natural Science Foundation of China [81300883]
  3. Wuhan Innovative Talent Development Funds
  4. Scientific Research Foundation for Returned Scholars, Tongji Hospital

向作者/读者索取更多资源

This article introduces a novel cytokine SOFAT related to bone remodeling, discusses its characteristics, location, and regulation, summarizes the clinical progress, and speculates on future therapeutic targets in diseases associated with bone remodeling.
The process of bone remodeling is connected with the regulated balance between bone cell populations (including bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte). And the mechanism of bone remodeling activity is related to the major pathway, receptor activator of nuclear factor kappaB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) signaling axis. Recently, researchers have found a novel cytokine secreted by activated T cells, which is related to osteoclastogenesis in the absence of osteoblasts or RANKL, leading to bone destruction. They name it the secreted osteoclastogenic factor of activated T cells (SOFAT). SOFAT has been proven to play an essential role in bone remodeling, like mediating the bone resorption in rheumatoid arthritis (RA) and periodontitis. In this review, we outline the latest research concerning SOFAT and discuss the characteristics, location, and regulation of SOFAT. We also summarize the clinical progress of SOFAT and assume the future therapeutic target in some diseases related to bone remodeling. (C) 2022Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science.

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