期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 2, 期 12, 页码 2127-2132出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.6b00459
关键词
drug delivery; stimuli responsive; photothermal; polymer; surface engineering
资金
- Youth Innovation Promotion Association of the Chinese Academy of Sciences
- Ministry of Education of the People's Republic of China [NCET-13-0547]
On-demand drug release within target site is critical for targeted drug delivery systems. We herein integrate the advantages of upper critical solution temperature (UCST) polymers, photo thermal agent, and red blood cell (RBC) membrane coating into a single drug delivery nanosystem and, for the first time, achieve remotely controlled UCST polymer-based drug delivery system that undergoes on-demand drug release within specified zone. When in laser-off state, the resulting nanosystem demonstrates significantly diminished drug self-leakage, owing to shielding by the RBC membrane coating. Upon laser irradiation, this system undergoes responsive drug release, likely because of particle swelling due to its UCST polymer component's hydrophobic-to-hydrophilic transition triggered by the rapid localized heating generated by its preloaded photothermal agent via photothermal effects. As a result, this drug delivery system exhibits spatiotemporally controlled cytotoxicity to cultured cells, efficiently eradicating irradiated cancerous cells without appreciably impacting nonirradiated ones, those similar to 0.7 cm away from the irradiation zone. This work may open an avenue to thermosensitive drug delivery systems potentially ideal for intravenous administration and inspire future efforts on biomedical applications of UCST polymers. KEYWORDS: drug delivery, stimuli responsive, photothermal, polymer, surface engineering
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