期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 2, 期 3, 页码 409-414出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.5b00553
关键词
nanotube diameter; nitinol; restenosis; primary human aortic endothelial and smooth muscle cells; collagen and elastin production
资金
- Alfred E. Mann Institute for Biomedical Engineering
- NSF-MRI [0821619]
- NSF-EAR [0949176]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0821619] Funding Source: National Science Foundation
- Division Of Earth Sciences
- Directorate For Geosciences [0949176] Funding Source: National Science Foundation
Current approaches to reducing restenosis do not balance the reduction of vascular smooth muscle cell proliferation with the increase in the healing of the endothelium. Building on our previous work, we present our study on the effects of Nitinol-based nanotubular coatings with different nanotube diameters on the reduction of restenosis. Here, we demonstrate that the nanotubular coatings reduced primary human aortic smooth muscle cell (HASMC) proliferation and increased the migration (by more than 4 times), collagen (by 2-3 times per cell) and elastin (by 5-8 times per cell) production of primary human aortic endothelial cells (HAEC). Furthermore, a significant increase in elastin and soluble collagen production of HAEC was observed with an increase in nanotube diameter. Our findings suggest that nanotubes-coated Nitinol may provide a surface conducive for HAEC reendothelialization while reducing the proliferation of HASMC.
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