期刊
2D MATERIALS
卷 3, 期 3, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/2053-1583/3/3/035013
关键词
large area graphene; nanopattern; scaffold; stem cell; tissue engineering
资金
- National Research Foundation of Korea (NRF) - Korea government [2011-0006268, 2012R1A1A2009165, NRF-2015R1D1A1A01059283, NRF-2016M3A9B4919374]
- 'Cooperative Research Program for Agriculture Science & Technology Development' Rural Development Administration, Republic of Korea [PJ0123022016]
- Chonnam National University
- Agricultural Robotics and Automation Research Center through Agriculture, Food and Rural Affairs Research Center Support Pro-gram, Ministry of Agriculture, Food and Rural Affairs [714002-7]
- National Research Foundation of Korea [2012R1A1A2009165, 2015R1D1A1A01059283, 2016M3A9B4919374] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Inspired by the hierarchical nanofibrous and highly oriented structures of natural extracellular matrices, we report a rational design of chemical vapor deposition graphene-anchored scaffolds that provide both physical and chemical cues in a multilayered organization to control the adhesion and functions of cells for regenerative medicine. These hierarchical platforms are fabricated by transferring large graphene film onto nanogroove patterns. The top graphene layer exhibits planar morphology with slight roughness (similar to 20 nm between peaks) due to the underlying topography, which results in a suspended structure between the nanoridges. We demonstrate that the adhesion and differentiation of human mesenchymal stem cells were sensitively controlled and enhanced by the both the nanotopography and graphene cues in our scaffolds. Our results indicate that the layered physical and chemical cues can affect the apparent cell behaviors, and can synergistically enhance cell functionality. Therefore, these suspended graphene platforms may be used to advance regenerative medicine.
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