期刊
CURRENT ONCOLOGY
卷 29, 期 9, 页码 6551-6563出版社
MDPI
DOI: 10.3390/curroncol29090515
关键词
pancreatic cancer; margin; pathology; prognosis
类别
资金
- Norwegian Cancer Society [212734-2019]
Pancreatic cancer has a poor prognosis, and surgical resection is the only curative treatment option. However, there is limited data on the prognostic impact of the resection margin status in distal pancreatectomy specimens, and the existing studies show divergent results due to small sample sizes and heterogeneity in pathology examination practices.
Pancreatic cancer is associated with a poor prognosis. While surgical resection is the only treatment option with curative intent, most patients die of locoregional and/or distant recurrence. The prognostic impact of the resection margin status has received much attention. However, the evidence is almost exclusively related to pancreatoduodenectomies, while corresponding data for distal pancreatectomy specimens are limited. The key data, such as the rate of microscopic margin involvement (R1), the site of margin involvement, and the impact of R1 on patient outcome, are divergent between studies and do not currently allow any general conclusions. The main reasons for the variability in the published data are the small size of the study cohorts and their heterogeneity, as well as the marked divergence in pathology examination practices. The latter is a consequence of the lack of concrete guidance, both for grossing and microscopic examination. The increasing administration of neoadjuvant chemo(radio)therapy introduces a further factor of uncertainty as the conventional definition of a tumour-free margin (R0) based on 1 mm clearance is inadequate for these specimens. This review discusses the published data regarding the prognostic impact of margin status in distal pancreatectomy specimens along with the challenges and uncertainties that are related to the assessment of the margins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据