期刊
CURRENT ONCOLOGY
卷 29, 期 9, 页码 6303-6313出版社
MDPI
DOI: 10.3390/curroncol29090495
关键词
apparent diffusion coefficient; head and neck; radiotherapy; gross tumour volume
类别
资金
- RSNA fellow grant
- Mike Hogg fund
- RANZCR research grants
- National Institute for Dental and Craniofacial Research (NIDCR) Academic Industrial Partnership Grant [R01DE028290]
- MD Anderson Steifel Oropharynx Research Program
- MD Anderson National Cancer Institute (NCI) Cancer Center Support Grant (CCSG) Radiation Oncology-Cancer Imaging Program (ROCIP) [P30CA016672-44]
- National Institutes of Health (NIH) NIBIB Research Education Programs for Residents and Clinical Fellows Grant [R25EB025787-01]
- NCI/NSF Joint Smart Connected Health Award [R01CA257814]
- NCI Early Phase Clinical Trials in Imaging and Image-Guided Interventions Program [1R01CA218148]
- NIH/NCI Cancer Center Support Grant (CCSG) Pilot Research Program Award from the UT MD Anderson CCSG Radiation Oncology and Cancer Imaging Program Seed Grant [P30CA016672]
- NSF Division of Civil, Mechanical, and Manufacturing Innovation (CMMI) [NSF 1933369]
- multidisciplinary the Radiation Oncology/Cancer Imaging Program of the MD Anderson Cancer Center Support Grant [P30CA016672-44, P30CA016672]
- MD Anderson Program in Image-guided Cancer Therapy
The PREDICT-HN study assessed the kinetics of imaging MR biomarkers during head and neck radiotherapy. It found that primary tumors and nodal disease exhibit different treatment responses based on the changes in tumor volume and ADC values.
Background: The PREDICT-HN study aimed to systematically assess the kinetics of imaging MR biomarkers during head and neck radiotherapy. Methods: Patients with intact squamous cell carcinoma of the head and neck were enrolled. Pre-, during, and post-treatment MRI were obtained. Serial GTV and ADC measurements were recorded. The correlation between each feature and the GTV was calculated using Spearman's correlation coefficient. The linear mixed model was used to evaluate the change in GTV over time. Results: A total of 41 patients completed the study. The majority (76%) had oropharyngeal cancer. A total of 36 patients had intact primary tumours that can be assessed on MRI, and 31 patients had nodal disease with 46 nodes assessed. Median primary GTV (GTVp) size was 14.1cc. The rate of GTVp shrinkage was highest between pre-treatment and week 4. Patients with T3-T4 tumours had a 3.8-fold decrease in GTVp compared to T1-T2 tumours. The ADC values correlated with residual GTVp. The median nodal volume (GTVn) was 12.4cc. No clinical features were found to correlate with GTVn reduction. The overall change in ADC for GTVn from pre-treatment was significant for 35th-95th percentiles in weeks 1-4 (p < 0.001). Conclusion: A discrepancy in the trajectory of ADC between primary and nodal sites suggested that they exhibit different treatment responses and should be analysed separately in future studies.
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