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Neelanjana Ray et al.
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Bo Chen
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Zheng Liu et al.
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Jacob J. Swidorski et al.
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Zeyu Lin et al.
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Jonathan M. Wagner et al.
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Eric P. Gillis et al.
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Gongpu Zhao et al.
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Jens Verheyen et al.
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Mark A. Wainberg et al.
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Nicolas A. Margot et al.
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Catherine S. Adamson et al.
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Mary Ann Checkley et al.
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Kurt Van Baelen et al.
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Akiko Baba et al.
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Patrick F. Smith et al.
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Isabelle Malet et al.
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Siddhartha A. K. Datta et al.
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Andrew V. Stachulski et al.
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R Xu et al.
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JDA Tyndall et al.
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J Zhou et al.
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F Li et al.
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J Takagi et al.
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Rate acceleration of the Baylis-Hillman reaction in polar solvents (water and formamide). Dominant role of hydrogen bonding, not hydrophobic effects, is implicated
VK Aggarwal et al.
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S Campbell et al.
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T Kanamoto et al.
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