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Does coronavirus disease 2019 kill more elderly men than women due to different hormonal milieu

JOURNAL OF MID-LIFE HEALTH (2022)

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Article Andrology

The relationship of serum testosterone levels with the clinical course and prognosis of COVID-19 disease in male patients: A prospective study

Ahmet Emre Cinislioglu et al.

Summary: The study found that lower serum total testosterone levels in male COVID-19 patients were associated with poor prognosis and fatal outcomes, indicating a potential role for testosterone in the pathogenesis of the disease. This could help clinicians determine the clinical course of COVID-19.

ANDROLOGY (2022)

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Article Andrology

Testosterone in males with COVID-19: A 7-month cohort study

Andrea Salonia et al.

Summary: Although total testosterone levels increased over time after COVID-19, more than 50% of men who recovered from the disease still had circulating testosterone levels suggestive for a condition of hypogonadism at 7-month follow-up. In as many as 10% of cases, testosterone levels even further decreased. Of clinical relevance, the higher the burden of comorbid conditions at presentation, the lower the probability of testosterone levels recovery over time.

ANDROLOGY (2022)

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Article Andrology

SARS-CoV-2, testosterone and frailty in males (PROTEGGIMI): A multidimensional research project

Andrea Salonia et al.

Summary: Males with SARS-CoV-2 infection are more susceptible to severe complications and have a higher fatality rate. Differences in hormonal milieu may play a significant role in this phenomenon, necessitating further research.

ANDROLOGY (2021)

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Review Andrology

Worse progression of COVID-19 in men: Is testosterone a key factor?

Vito A. Giagulli et al.

Summary: Testosterone levels may affect the progression of COVID-19 in men, with low levels predisposing to endothelial dysfunction, thrombosis, and defective immune response. This can ultimately lead to impaired viral clearance and systemic inflammation, especially in critically ill individuals. Further studies are needed to confirm these findings and identify appropriate therapeutic strategies.

ANDROLOGY (2021)

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Article Urology & Nephrology

COVID-19 Infection in Men on Testosterone Replacement Therapy

Amarnath Rambhatla et al.

Summary: The study suggests that testosterone replacement therapy (TRT) is not associated with worse clinical outcomes in men diagnosed with COVID-19.

JOURNAL OF SEXUAL MEDICINE (2021)

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Article Andrology

Effects of SARS-CoV-2 infection on male sex-related hormones in recovering patients

Hui Xu et al.

Summary: This study found that in males recovering from SARS-CoV-2 infection, most sex-related hormones (such as T, FSH, and LH levels) remain within normal ranges, and there are no significant associations between T levels and disease duration or severity.

ANDROLOGY (2021)

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Article Urology & Nephrology

SARS-CoV-2 Pneumonia Affects Male Reproductive Hormone Levels: A Prospective, Cohort Study

Mustafa Kadihasanoglu et al.

Summary: This study compared male reproductive hormone levels between patients with COVID-19, non-COVID-19 respiratory tract infection cases, and controls, finding that COVID-19 is associated with decreased TT levels and increased LH and prolactin levels. More severe COVID-19 leads to greater reduction in TT levels and prolonged hospitalization.

JOURNAL OF SEXUAL MEDICINE (2021)

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Article Andrology

Severely low testosterone in males with COVID-19: A case-control study

Andrea Salonia et al.

Summary: This study revealed that male patients with COVID-19 had lower levels of androgens, particularly testosterone, upon hospital admission, indicating a high prevalence of hypogonadism. Furthermore, the research showed an independent association between SARS-CoV-2 infection and decreased testosterone levels, as well as a higher risk of hypogonadism. Lower testosterone levels were also linked to increased risk of ICU admission and death outcomes.

ANDROLOGY (2021)

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Review Nutrition & Dietetics

The Looming Effects of Estrogen in Covid-19: A Rocky Rollout

Hayder M. Al-kuraishy et al.

Summary: Studies have shown that women have a powerful immunomodulating effect against Covid-19 through the effect of estrogen. Estrogens have significant anti-inflammatory and immuno-modulatory effects in Covid-19, reducing SARS-CoV-2 infectivity. Future clinical trials and prospective studies will help elucidate and confirm the protective effect of estrogen against Covid-19.

FRONTIERS IN NUTRITION (2021)

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Article Multidisciplinary Sciences

Estrogen and COVID-19 symptoms: Associations in women from the COVID Symptom Study

Ricardo Costeira et al.

Summary: The study found that menopausal women had higher rates of predicted COVID-19, while users of combined oral contraceptive pills had lower rates. Hormone replacement therapy usage did not consistently show associations with COVID-19. However, caution should be taken when interpreting the results due to certain limitations in the data collection.

PLOS ONE (2021)

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Article Obstetrics & Gynecology

Coronavirus disease-19 and fertility: viral host entry protein expression in male and female reproductive tissues

Kate E. Stanley et al.

FERTILITY AND STERILITY (2020)

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Article Obstetrics & Gynecology

No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019

Feng Pan et al.

FERTILITY AND STERILITY (2020)

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Article Endocrinology & Metabolism

Effect of serum total testosterone and its relationship with other laboratory parameters on the prognosis of coronavirus disease 2019 (COVID-19) in SARS-CoV-2 infected male patients: a cohort study

Selahittin Cayan et al.

AGING MALE (2020)

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Article Andrology

COVID-19 pneumonia causes lower testosterone levels

Sezgin Okcelik

ANDROLOGIA (2020)

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Article Medicine, General & Internal

Evidence for treatment with estradiol for women with SARS-CoV-2 infection

Ute Seeland et al.

BMC MEDICINE (2020)

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Article Medicine, Research & Experimental

Role of testosterone in COVID-19 patients - A double-edged sword?

Aneela N. Hussain et al.

MEDICAL HYPOTHESES (2020)

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