期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 18, 期 8, 页码 3251-3265出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.71768
关键词
Circulating tumor cell (CTC); Early detection; Liquid biopsy; Human cancers; Cancer metastasis
资金
- Research Council of the University of Hong Kong [104004092, 104004460]
- Wong's donation [200006276]
- Gaia Family Trust of New Zealand [200007008]
- Research Grants Committee (RGC) of Hong Kong, HKSAR [740608, 766211, 17152116, 17119621, 17121419]
- Health and Medical Research Fund [15162961, 16172751]
- Enhanced new staff start-up fund [204610519]
- Pre-emptive retention fund [202007002]
Cancer is a severe disease with high morbidity and mortality globally. Early detection is crucial for successful treatment, but remains challenging. Various screening methods are widely used, but each has limitations and potential harms. Liquid biopsy is a convenient and non-invasive approach for early tumor screening and diagnosis.
Cancer is a severe disease with high morbidity and mortality globally. Thus, early detection is emerging as an important topic in modern oncology. Although the strategies for early detection have developed rapidly in recent decades, they remain challenging due to the subtle symptoms in the initial stage of the primary tumor. Currently, tumor biomarkers, imaging, and specific screening tests are widely used in various cancer types; however, each method has limitations. The harms are even overweight against the benefits in some cases. Therefore, early detection approaches should be improved urgently. Liquid biopsy, for now, is a convenient and non-invasive way compared to the traditional tissue biopsy in screening and early diagnosis. Circulating tumor cells (CTCs) are vital in liquid biopsy and play a central role in tumor dissemination and metastases. They have promising potential as cancer biomarkers in early detection. This review updates the knowledge of the biology of CTC; it also highlights the CTC enrichment technologies and their applications in the early detection of several human cancers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据