期刊
REGENERATIVE BIOMATERIALS
卷 9, 期 -, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/rb/rbac064
关键词
cardiovascular disease; extracellular vesicle; vascular regeneration; biomedical engineering
资金
- National Natural Science Foundation of China [12032007, 31971242]
- Chongqing Science and Technology Bureau [cstc2019jcyj-zdxmX0028]
- Chongqing Municipal Education Commission, China [KYYJ202001]
- Guizhou Provincial Science and Technology Projects [Qiankehejichu(2018)1103]
This article discusses the progression of cardiovascular diseases such as atherosclerosis and myocardial infarction, emphasizing the role of extracellular vesicles (EVs) and the advancements of bioengineered EVs in biomedical applications for targeted regenerative therapy.
The progression of cardiovascular diseases such as atherosclerosis and myocardial infarction leads to serious vascular injury, highlighting the urgent need for targeted regenerative therapy. Extracellular vesicles (EVs) composed of a lipid bilayer containing nuclear and cytosolic materials are relevant to the progression of cardiovascular diseases. Moreover, EVs can deliver bioactive cargo in pathological cardiovascular and regulate the biological function of recipient cells, such as inflammation, proliferation, angiogenesis and polarization. However, because the targeting and bioactivity of natural EVs are subject to several limitations, bioengineered EVs have achieved wide advancements in biomedicine. Bioengineered EVs involve three main ways to acquire including (i) modification of the EVs after isolation; (ii) modification of producer cells before EVs' isolation; (iii) synthesize EVs using natural or modified cell membranes, and encapsulating drugs or bioactive molecules into EVs. In this review, we first summarize the cardiovascular injury-related disease and describe the role of different cells and EVs in vascular regeneration. We also discuss the application of bioengineered EVs from different producer cells to cardiovascular diseases. Finally, we summarize the surface modification on EVs which can specifically target abnormal cells in injured vascular.
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