A protein-conjugated photosensitizer with mitochondrial targeting for enhanced photodynamic therapy

A protein-conjugated photosensitizer with mitochondrial targeting ability was synthesized to enhance the therapeutic effects of PDT. The ROS produced by the photosensitizer under laser irradiation could effectively destroy key intracellular proteins and disrupt mitochondrial redox homeostasis, thereby causing mitochondrial dysfunction and irreversible cell death.

Automated summary

A protein-conjugated photosensitizer with mitochondrial targeting ability was synthesized to enhance the effectiveness of photodynamic therapy. The reactive oxygen species generated by the photosensitizer can effectively destroy key intracellular proteins, disrupt mitochondrial redox homeostasis, leading to mitochondrial dysfunction and irreversible cell death.