4.1 Article

Screening of bacterial DNA in bile sampled from healthy dogs and dogs suffering from liver- or gallbladder-associated disease

期刊

JOURNAL OF VETERINARY MEDICAL SCIENCE
卷 84, 期 7, 页码 1019-1022

出版社

JAPAN SOC VET SCI
DOI: 10.1292/jvms.22-0090

关键词

bile; bile microbiota; gallbladder; hospitalized dog; laboratory dog

资金

  1. Veterinarian Medical Development Co., Ltd
  2. Azabu University staff

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This study analyzed the microbial community in the canine gallbladder and found a specific bacterial community present in the bile of diseased dogs, while no bacteria were detected in healthy dogs.
Although the biliary system is generally aseptic, gallbladder microbiota has been reported in humans and some animals apart from dogs. We screened and analyzed the bacterial deoxyribonucleic acid in canine gallbladders using bile sampled from 7 healthy dogs and 52 dogs with liver-or gallbladder-associated disease. PCR screening detected bacteria in 17.3% of diseased dogs (9/52) and none in healthy dogs. Microbiota analysis of PCR-positive samples showed that the microbial diversity differed between liver-and gallbladder-associated disease groups. Thus, a specific bacterial community appears to occur at a certain frequency in the bile of diseased dogs.

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