期刊
THERANOSTICS
卷 12, 期 15, 页码 6779-6808出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.74308
关键词
electrochemiluminescence; potential-resolved strategy; ratiometric electrochemiluminescence sensors; multiplex electrochemiluminescence sensors; multicolor electrochemiluminescence sensors
资金
- Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0330, cstc2021jsyj-yzysbA0057]
- National Natural Science Foundation of China [31971242, 12032007]
- Chongqing Science, the Technology Bureau [cstc2019jcyj-zdxmX0028, cstc2020jscx-msxmX0132]
- Project of Tutorial System of Medical Undergraduate in Lab Teaching & Management Center in Chongqing Medical University [LTMCMTS202005]
- JinFeng Laboratory Foundation, Chongqing, China [jfkyjf202203001]
The potential-resolved strategy has great value in ECL biosensing, especially in ratiometric ECL sensors, multiplex ECL sensors, and multicolor ECL sensors. It can provide more accurate analysis results and broader application prospects.
The potential-resolved strategy has gradually demonstrated its distinct values in electro-chemiluminescence (ECL) bio-sensing due to its superior characteristics, such as low instrument requirement, short assay time, and improved sample throughput, in conjunction with spatial-and spectrum-resolved techniques. It has recently been widely generalized into versatile multiple-signal ECL analytic platforms, especially in ratiometric and multiplex ECL sensors, in accordance with some specific principles. Furthermore, luminophore pairs with potential-and wavelength-resolved properties have been utilized to visualize biosensors that display multiple colors depending on analyte concentration. However, only a few comprehensive reports on the principles, construction, and application of various ECL sensors in potential-resolved schemes have been published. This review aims to recount the potential-resolved strategy applying to (a) ratiometric ECL sensors, (b) multiplex ECL sensors, and (c) multicolor ECL sensors and to discuss the distinctions and connections among the application principles of these strategies. Finally, the future prospects of ECL-based potential-resolved analysis are explored.
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