Long-term humoral immunity decline in hemodialysis patients following severe acute respiratory syndrome coronavirus 2 vaccination: A cohort study

Article Urology & Nephrology

Impact of tozinameran (BNT162b2) mRNA vaccine on kidney transplant and chronic dialysis patients: 3-5 months follow-up

Iddo Z. Ben-Dov et al.

Summary: This study aimed to determine the humoral immunogenicity of tozinameran in patients requiring chronic renal replacement therapy and its impact on COVID-19 morbidity. The results showed that dialysis patients and kidney transplant recipients had reduced antibody response to the COVID-19 vaccine, and this reduced response was associated with higher infection rates.

JOURNAL OF NEPHROLOGY (2022)

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Article Multidisciplinary Sciences

Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

Peter B. Gilbert et al.

Summary: In the COVE phase 3 clinical trial, neutralizing and binding antibodies were measured in vaccine recipients to determine their correlation with COVID-19 risk and vaccine efficacy. The results showed that these immune markers were inversely associated with COVID-19 risk and directly associated with vaccine efficacy. Postvaccination neutralization titers of 10, 100, and 1000 correlated with estimated vaccine efficacies of 78%, 91%, and 96% respectively.

SCIENCE (2022)

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Article Urology & Nephrology

SARS-CoV-2 Antibody Response After a Third Dose of the BNT162b2 Vaccine in Patients Receiving Maintenance Hemodialysis or Peritoneal Dialysis

Ilias Bensouna et al.

Summary: The effectiveness of a third dose of the BNT162b2 vaccine in patients undergoing dialysis treatment was investigated, and it was found that the third dose significantly increased antibody levels.

AMERICAN JOURNAL OF KIDNEY DISEASES (2022)

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Article Transplantation

Haemodialysis patients show a highly diminished antibody response after COVID-19 mRNA vaccination compared with healthy controls

Benedikt Simon et al.

Summary: HD patients had significantly lower anti-SARS-CoV-2 S antibody titres compared to controls 21 days after vaccination. The HD group experienced fewer adverse events than the control group. There was no correlation between the antibody response to Hepatitis B vaccination and the SARS-CoV-2 vaccine.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)

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Article Urology & Nephrology

Immunogenicity of SARS-CoV-2 Vaccine in Dialysis

Eduardo Lacson et al.

Summary: Most patients on maintenance dialysis responded well to two doses of BNT162b2/Pfizer or mRNA-1273/Moderna vaccines, showing promise for short-term protection, but further studies are needed to evaluate long-term antibody durability and the necessity of booster doses. Research is also needed to explore options for patients who do not show a serologic response.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Immunology

Immunogenicity of COVID-19 Tozinameran Vaccination in Patients on Chronic Dialysis

Eva Schrezenmeier et al.

Summary: The study found that patients on chronic dialysis may have impaired immunogenicity to SARS-CoV-2 vaccines, but exhibit a strong immune response three to four weeks after the second dose. However, their seroconversion rates and antibody titers were lower compared to a cohort of vaccinees of similar age, indicating the need for further attention and research in this vulnerable group.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Health Care Sciences & Services

COVID-19 Vaccines in Patients with Maintenance Hemodialysis

Cheng-Chieh Yen et al.

Summary: The efficacy of COVID-19 vaccination in maintenance hemodialysis patients remains uncertain and further studies are needed to explore the effectiveness in this population.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Urology & Nephrology

Outcomes of patients with end -stage kidney disease hospitalized with COVID-19

Jia H. Ng et al.

KIDNEY INTERNATIONAL (2020)

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Long-term humoral immunity decline in hemodialysis patients following severe acute respiratory syndrome coronavirus 2 vaccination: A cohort study

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