期刊
COMPUTATIONAL BIOLOGY AND CHEMISTRY
卷 100, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.compbiolchem.2022.107745
关键词
BAT; ACT transporters; Molecular evolution; Phylogenetic tree; Oryza sativa
This study characterizes the structural, functional, and evolutionary features of seven ACT/BAT transporters in rice using bioinformatics-based analytical studies. It suggests that these transporters play important roles in regulating amino acid transportation and provides clues on their evolutionary structural diversification.
The Amino Acid-Polyamine-Organocation (APC) family transporters containing BAT/ACT (amino acid/choline transporters), PHS/LAT (polyamine H+-symporters) and CAT (cationic amino acid transporters) type transporters are ubiquitously reported in plants. ACT (containing BAT genes) which mediates bidirectional amino acid transport has been poorly characterized till date. In the present study, bioinformatics-based analytical studies have been performed to characterize the structural, functional, and evolutionary features of seven ACT/BAT transporters in the model crop Oryza sativa. Sequence homologies with allied transporters suggest that these seven transporter proteins can also have important roles in regulating amino acid transportation. Evolutionary and phylogenetic study of OsBATs proteins using different statistical models based on CDS, Protein, and UTR regions have brought forward some valuable information regarding their way and patterns of diversification over the time, possibly due to the influence of their prevailing growth conditions. Computational analyses based on promoter regions, exon-intron structural patterns, conserved motifs, secondary and tertiary structures and ligand binding sites with probable ligand names provided clues on their evolutionary structural diversification indicating changes in their functional specification probably needed to combat with the changing environment.
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