3.9 Article

Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices

期刊

ACS POLYMERS AU
卷 2, 期 2, 页码 97-107

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acspolymersau.1c00045

关键词

Nanocellulose; Chitosan; Layer-by-layer meshes; Medical implants; Direct ink writing

资金

  1. Business Finland TUTLI fund [211795, BF 6108/31/2019]
  2. Finnish Foundation for Technology Promotion (TES)
  3. ERC [788489]
  4. Canada Excellence Research Chair initiative
  5. European Research Council (ERC) [788489] Funding Source: European Research Council (ERC)
  6. Academy of Finland (AKA) [211795] Funding Source: Academy of Finland (AKA)

向作者/读者索取更多资源

Direct ink writing is used to synthesize layer-by-layer meshes using renewable polysaccharides, which demonstrate excellent mechanical performance, wet stability, and biocompatibility, making them suitable for biomedical implants.
Direct ink writing via single or multihead extrusion is used to synthesize layer-by-layer (LbL) meshes comprising renewable polysaccharides. The best mechanical performance (683 +/- 63 MPa modulus and 2.5 +/- 0.4 MPa tensile strength) is observed for 3D printed structures with full infill density, given the role of electrostatic complexation between the oppositely charged components (chitosan and cellulose nanofibrils). The LbL structures develop an unexpectedly high wet stability that undergoes gradual weight loss at neutral and slightly acidic pH. The excellent biocompatibility and noncytotoxicity toward human monocyte/macrophages and controllable shrinkage upon solvent exchange make the cellular meshes appropriate for use as biomedical implants.

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