期刊
NUCLEUS
卷 7, 期 1, 页码 13-19出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19491034.2016.1149665
关键词
capsid; egress; herpes; nucleus; nuclear actin; ring-sheet
类别
资金
- National Institutes of Health (NIH) [NS033506, NS060699]
- DFG [BO 4158/1-1, BO 4158/2-1]
Herpesviruses are large DNA viruses that utilize the host nucleus for genome replication as well as capsid assembly. After maturation, these 125nm large capsid assemblies must cross the nucleoplasm to engage the nuclear envelope and bud into the cytoplasm. Here we summarize our recent findings how this motility is facilitated. We suggest that herpesvirus induced nuclear remodeling allows capsids to move by diffusion in the nucleus and not by motor-dependent transport.
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