期刊
ADVANCED NANOBIOMED RESEARCH
卷 2, 期 11, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anbr.202200065
关键词
cancer theranostics; combined therapies; molybdenum dichalcogenides; molybdenum oxides; photothermal therapy
资金
- National Natural Science Foundation of China [22005259, 52102348]
- City University of Hong Kong [9610495, 9680297, 7020013]
- National Natural Science Foundation of China (NSFC National Natural Science Foundation of China) [NSFC: 21971007]
- Beijing Natural Science Foundation [2212044]
- PhD Research Startup Foundation [PXY-BSQD-2022032]
Molybdenum is an essential trace dietary element for human survival, and its nanomaterials have been extensively explored in biomedical applications, especially in photothermal cancer treatment. The synthesis and surface functionalization of molybdenum nanomaterials, as well as their combined therapies for cancer treatment, have been studied. Toxicity assessment of molybdenum nanomaterials is also an important topic of research.
Molybdenum (Mo) is a trace dietary element that is essential for human survival. Several molybdenum-containing enzymes (e.g., aldehyde oxidase, xanthine oxidase and sulfite oxidase) are associated with key metabolic activities in the body. Molybdenum-based nanomaterials (Mo-NMs), including molybdenum dichalcogenides, molybdenum oxides, molybdenum-based polyoxometalates, and molybdenum-based nanocomposites, have been extensively explored in biomedical applications including photothermal therapy (PTT) because of their unique chemical and physical properties as well as excellent biocompatibility and biodegradability. PTT, which relies on converting the near-infrared (NIR) light energy into thermal energy to achieve therapeutic effects, has attracted considerable attention in past decades for cancer treatment because of its localized and trigger-activated therapeutic effects. In this review, the state-of-the-art progress on Mo-NMs for photothermal cancer treatment is summarized. The classification, synthesis, and surface functionalization of Mo-NMs are first introduced. Then the discussion of PTT and PTT-combined therapies of Mo-NMs for effective cancer treatment is focused on. Following that, the toxicity assessment of Mo-NMs is also discussed. Finally, a short discussion on the challenges and future prospects in this field is presented.
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